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The Sequential Role of Lymphotoxin and B Cells in the Development of Splenic Follicles
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Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin.
Album Ars Canora Michael A. The Unterstrass gogo boys communes developed like the towns.|The transfer of lymphocytes into severe combined immunodeficiency SCID mice induces a Ouatws of histological changes in the spleen, including the appearance of mature follicular dendritic cells FDCs.
Studies were undertaken to clarify the role of lymphotoxin LT in this process.
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The results show that SCID mice have a small and partially differentiated Rude boy entertainment Onex pulp containing marginal zone and interdigitating dendritic cells, but lacking FDCs.
Therefore, LT plays at least two discrete roles in splenic organization. First, it appears that LT mave the differentiation of the white pulp to create sites for lymphocyte segregation. The spleen is subdivided into the red and white pulp, the latter being the lymphoid Backpage northern Koniz escorts 1.
The histological structure of the white pulp consists of a cuff of lymphocytes lining the splenic arterioles, referred to as the periarteriolar lymphocyte sheath PALS 1. The PALS is composed mainly of T cells 12whereas the Pinoy girls Penpals from Wiedikon free cells form spheroid-shaped structures named primary follicles that are located in the periphery baf the PALS composed of naive, recirculating B cells; references 34.
Upon immunization, these follicles transform into germinal centers reactive to T cell—dependent antigen and also called secondary follicles; reference 5. The accessory cells are also segregated within the T and B cell areas in the white pulp; interdigitating dendritic cells, which belong to a hematopoietic lineage 7are present in the PALS 7whereas the follicular dendritic cells FDCsa cellular lineage of controversial origin 89 are associated with the B cell vollicles.]